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To this end, a recent study by Crobach et al

Two transcription factors, DREB1 and DREB2, with an EREBP/AP2 DNA binding domain separate two cellular signal transduction pathways in drought- and low-temperature-responsive gene expression, respectively, in Arabidopsis

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When this is found, consideration should be given to the possibility of any one of a number of rarely encountered conditions such as Peutz-Jehgers syndrome, Laugier-Hunziger syndrome, Bannayan-Riley-Ruvalcaba syndrome, LEOPARD syndrome, and the several syndromes in which lentigines and cardiocutaneus myxomas are found