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However, we observed shorter neurite length in scramble neurons treated with 1M SP600125, suggesting that 1M is an effective concentration to inhibit JNK activity in neurite formation (data not shown)
Ferroptosis is one of the novel mechanisms of anesthesia-induced neurotoxicity in developing brain Ferroptosis is another novel kind of programmed cell death characterized by iron-dependent lipid peroxides accumulation ( Meanwhile, exposure to sevoflurane might also lead to iron-induced neurotoxicity in the hippocampus and cognitive dysfunction by upregulating NMDA receptors and enhancing divalent metal transporter 1 (DMT1)-mediated iron upregulation and iron release from lysosome ( Clinical concentration might lead to dysregulation of gut microbiota The dysregulation of the gut microbiota might also influence the immature brain

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