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Dabrafenib treatment significantly upregulated the expression of Axl receptor tyrosine kinase (Axl) in the spinal cord tissues of EAE mice, increased the expression of System Xc , GPX4, and Ferritin, and decreased the expression of CD71, ACSL4, and POR

doi: 10.3389/fendo.2020.00160 [DOI] [PMC free article] [PubMed] [Google Scholar]

Knockout of FKBP5 leads to upregulated phosphorylation of GR at the Ser240 and Ser243 sites (362), resulting in decreased levels of pro-inflammatory cytokines such as TNF-, IL-1, IL-6, nerve growth factor (NGF), and brain-derived neurotrophic factor (BDNF) (363)

Funding The institutions are funded by Fundao para a Cincia e Tecnologia/Ministrio da Cincia , Tecnologia e Ensino Superior (FCT/MCTES, Portugal) through national funds to iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020) and the Associated Laboratory LS4FUTURE (LA/P/0087/2020)