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532 However, the overexpression of SIRT1 displays protection against abnormal motor function, cortical and striatal atrophy and loss of striatal neurons in the transgenic HD mice via regulating mitochondrial function
Epithelial barriers in homeostasis and disease

No adverse interaction between the two is documented in the research literature

Superimposing a tonic pharmacological brake on top of this feedback system creates competing signals, and it would be unsurprising if intestinal feedback partially normalized emptying over time even while the drug is present
