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Pharmacol Rev 65:223254 Allouche S, Noble F, Marie N (2014) Opioid receptor desensitization: mechanisms and its link to tolerance

For example, aconitase has long been recognized as a sensitive index of steady-state superoxide, and loss of mitochondrial aconitase activity has been observed in many conditions where excessive superoxide is expected to be present, including Sod2 mutants (Nojiri et al., 2006

Both compounds are among the most researched peptides for tissue repair and recovery, and the combination is studied for synergistic effects on healing speed, angiogenesis, and musculoskeletal recovery

This could reduce the protection that these proteins provide to dopaminergic neurons, increasing their vulnerability to oxidative stress damage (129, 220)
