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Electron microscopy performed in aged non-human primates and rodents have further clarified this deterioration by revealing the structural alterations present in the myelin sheath, such as redundant myelination and reduced myelin thickness (Figure 1

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Additionally, the antioxidant enzyme activities of GP and superoxide dismutase were reported to be dysregulated in red blood cells and serum of obese individuals compared to controls (27, 28)

IRI Ischemia reperfusion injury (IRI) is also a common type of chronic liver disease