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Any linker that is known in the art may be used in the ADCs of the present invention, e.g., bifunctional agents (such as dialdehydes or imidoesters) or branched hydrazone linkers (see, e.g., U.S

The kynurenine connection: how exercise shifts muscle tryptophan metabolism and affects energy homeostasis, the immune system, and the brain

NICE guidelines (NG49) emphasise that weight loss, dietary changes, and increased physical activity are the most effective interventions for improving liver health in NAFLD

Importantly, other RTKs are also known to be involved in NMDAR-mediated OIH, including BDNF-TrkB signaling in the spinal dorsal horn