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Elegant 13 C-NMR analysis ( in vivo injection of labeled glucose, or in some cases acetate, and determination of labeled metabolites) has shown that the glutamine flux in the cycle, V gln in the 13 C-NMR studies, is slightly greater than the flux, V cyc in the 13 C-NMR studies, of released transmitter glutamate and GABA in the opposite direction (Rothman et al., 2011), and that GABA fluxes account for up to 20% of total flux in V cyc (Patel et al., 2005
Based on earlier data, there was a lot of expectation that CagriSema would come out on top
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