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Keywords: Basal insulin, GLP-1, Glycaemic control, Network meta-analysis, Semaglutide, Systematic review, Type 2 diabetes Key Summary Points Digital Features This article is published with digital features, including a summary slide, to facilitate understanding of the article

The highlighted region indicates the distinctive triple-proline motif (P3-P4-P5) that confers exceptional structural rigidity and acid stability

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