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2.6.1 Basic science research Mitochondria are a major source of ROS production during oxidative metabolism, although the overproduction of ROS leads to mitochondrial dysfunction, which is linked to diseases like PD and AD

Be prepared to treat anaphylactic reactions regardless of the precautions taken

Among them, IGF/IGF-1R signals can improve radiotherapy sensitivity by activating a series of signal transduction events involved in DNA damage repair

An accumulation of TCA intermediates may subsequently have an impact on the macrophage phenotype, e.g., by contributing to a pro-inflammatory phenotype [e.g., as shown for succinate (Tannahill et al., 2013) and oxaloacetate (Infantino et al., 2011)] or by triggering innate immune memory [for fumarate ( 4.2.1 TCA intermediate accumulation in M1 and trained macrophages More specifically, increased glutamine uptake in LPS-stimulated macrophages triggered the accumulation of succinate, which stabilized HIF1 and thereby increased the expression of the inflammatory mediator IL-1 (Tannahill et al., 2013)