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This technique is important for instances relating to high-risk screening, preoperative staging, and postoperative evaluation

Targeting hepatic macrophages to treat liver diseases

The intestine is not only the central place for digestion and absorption but also the largest immune organ of the body, which can effectively prevent harmful substances such as external pathogens from invading the body The damage of the intestinal epithelial barrier increases intestinal permeability and leads to the invasion of the internal environment by adverse external factors (Pcha, 2000)

After polyubiquitination, the target protein dissociates from PROTAC and follows the normal UPS pathway, where it is recognized by the 26S proteasome and degraded into small peptide fragments 24