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TSC-deficient cells were found to have depleted IRS-1 mRNA, an effect that is reversed by treatment with rapamycin, which inhibits unrestrained mTORC1 activation (122, 290)
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Proactive dose reduction of these concurrent agents is often necessary before tirzepatide escalation
Loh E, Mirkowski M, Agudelo AR, Allison DJ, Benton B, Bryce TN, et al
