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Further studies are needed to evaluate suitable dose, route and time of administration to confirm NAC efficacy as an adjuvant treatment for severe form of SARS-CoV-2 infection

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3 In normoxia, HIF1A protein is targeted for degradation by cytosolic prolyl hydroxylases, while in hypoxia, these prolyl hydroxylases are inhibited, allowing HIF1A to translocate to the nucleus, dimerize with HIF1 protein, and the dimer then binds to hypoxia response elements to modulate transcription of target genes, prompting changes in metabolism and angiogenesis to promote survival