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Structural changes such as cardiomyopathy, cardiac hypertrophy, interstitial cardiac fibrosis, endothelial dysfunction, and contractile protein failure can result from elevated oxidative stress in cardiac tissue (Emran et al
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Specifically, thiamine is important for glucose metabolism [51] and type 2 diabetics have been observed to have lower-than-average thiamine levels, suggesting that some degree of thiamine deficiency may play a role in the onset of diabetes
