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Consistent with our previous data which indicated a protective role of GSH under cystine-deprived conditions, cell death was most severe when both cystine and GSH were depleted in HepG2 cells (Fig

Endothelial dysfunction and cardiovascular disease The maintenance of a healthy endothelium is of utmost importance in the regulation of various cardiovascular functions, including but not limited to blood flow and fibrinolysis, hemostasis, vascular tone, angiogenesis, monocyte/leukocyte adhesion, and platelet aggregation

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Working synergistically, Bcrp, Mrp-2, and P-gp eliminate a multitude of drugs absorbed across tissue barriers (Chang et al., 2011)