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Description
Sildenafil was the first PDE5 inhibitor accepted for the management of PAH
These studies report: Improvement in skin tone and elasticity Mild reduction in melanin index No major adverse effects in studied dosages However, questions remain around: Ideal dosage Duration of therapy Long-term safety Best delivery system Thats why more large-scale, double-blind, placebo-controlled trials are needed to make firm recommendations
Resveratrol has better absorption than curcumin but is still rapidly metabolized
It comes in three forms: Eumelanin: Responsible for darker pigments such as brown and black
