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Primary outcome measures The primary outcome measures were: Pain intensity in patients with shingles during the whole study period was judged by the attending physician

These capsules are vegan and vegetarianfriendly, using liquid inside a hydroxypropyl methylcellulose capsule, making them suitable for plantbased diets

Taken together, APS functions as an anti-inflammatory agent in animals and exerts its anti-inflammation mainly by inhibiting NF-B signaling pathways and reducing expression of pro-inflammatory cytokines

This time-based validation design makes the validation set a temporal validation cohort, which is not a methodological limitation but rather a more stringent test of the model's generalizability to assess its stability in an evolving clinical environment