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Chromatin immunoprecipitation (ChIP) demonstrated increased occupancy of H2AX and decreased occupancy of all three acetylation marks at DSBs in both IDH1 inhibitor-treated and TMLHE-knockdown cells (Fig

It has been reported that muscle l-carnitine content increased following l-carnitine long-term oral administration [29,44,45] whereas failed to show elevated levels after short-term supplementation [43,46]

However, its metabolic conversion by gut microbiota into TMAO raises significant concerns due to the association of elevated TMAO levels with cardiovascular diseases like atherosclerosis, MI, stroke, and HF