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Deficiency may also occur in those who have undergone bariatric surgery, follow a strict vegetarian diet, or have used antacids or proton pump inhibitors long-term
doi: 10.1124/jpet.109.155176 Pubmed Abstract CrossRef Google Scholar View reference in article 79 WengQWangJWangJTanBWangJWangHet al

If standardized peptide formulations can be verified and administered within controlled protocols, these agents may represent a future adjunct to evidence-based perioperative care, particularly in populations undergoing TJA where wound healing, metabolic health, and inflammatory regulation strongly influence outcomes

This can be particularly important for people who have difficulty absorbing B vitamins due to certain medical conditions or digestive issues
