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On the other hand, TAK1 activates MAPK, which further activates AP-1 (a heterodimer of c-Jun), which translocates to the nucleus and coordinates with NF-B to initiate transcription of various inflammatory cytokines, chemokines, and co-stimulators

Studies have confirmed that Nrf2 is expressed in ovarian granulosa cells and plays a critical role in oxidative stress response and iron homeostasis (72)

The main focus of our experiments is to identify transcription factor genes that program differentiation events and determine how they form regulatory networks that program seed differentiation and function