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Common symptoms include frequent falls, trouble rising from a sitting or lying position, a waddling gait, and enlarged calf muscles

Therefore, considering the important role of mitochondria at all stages of AD, even the pre-MCI stage, mitochondrial dysfunction may play a crucial role as a primary or secondary event in AD, and targeting mitochondrial function may represent promising therapeutic targets

Expert Rev Proteomics (2009) 6:64759.10.1586/epr.09.86 40 ShiJWittke-ThompsonJKBadnerJAHattoriEPotashJBWillourVLet alClock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm
