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High NAD + level occurs in fasting and has been associated with health outcomes in model systems, while low NAD + /NADH ratio occurs in specific diseases

The average nonvegetarian stores 2,000-3,000 g B12 (5), while losing only about 3 g/day (6)

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Survival assay Measurement of life span in wild type and park 13 flies was essentially performed as per established protocols 58
