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Why it happens: The rise of obesity in T1D is shaped by global lifestyle trends, genetics, and epigenetics , but also by treatment itself
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However, given that ANGPTL3 activity is positively correlated to increased levels of phospholipid-rich HDL, which is highly active at cholesterol transport, there may be risks to blocking ANGPTL3 activity entirely
In contrast, most of the other MPTP and rotenone-induced cellular and animal models are acute, and the concentrations of rotenone or MPTP used are more than sufficient to completely inhibit complex I [17, 35]
