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The vaccine is supplied in two single-dose vials, one containing the lyophilized antigen component and the other containing the adjuvant suspension component

Whereas 5,10-methyleneTHF is used as a methyl donor by Thymidylate synthase (TYMS) to convert deoxyuridine monophosphate (dUMP) into deoxythymidine monophosphate (dTMP), generating DHF to re-enter the cycle
