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This offers convenience but removes the flexibility to adjust individual component doses

To a large extent, this tolerance development can be compensated for by gradually titrating the medication dose upwards, usually by adding a second dose in the early afternoon to provide reasonable all-day appetite control

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Deamidation of N 392 reveals only one peak and one product, which is consistent with the work of Robinson and Robinson that proposes that asparagine deamidates mainly by hydrolysis forming only aspartic acid unless it is followed by a glycine on the C-terminus side