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For example, injectable pyridoxine solutions may contain aluminum as a trace impurity, and with prolonged use in patients with renal impairment (especially premature neonates with immature kidneys) there is a risk of aluminum accumulation and toxicity

Adams JF, Ross SK, Mervyn L, Boddy K and King P, 1971

By inhibiting PNP, ImmH also leads to an accumulation of deoxyguanosine triphosphate, which can induce apoptosis in certain cell types, such as T cells

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