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Diol:epoxide ratios, which are a reflection of sEH activity, were also not significantly different between DMSO and control, although the ratio for the DHA metabolites (DiHDPE:EpDPE) was trending toward significance (Figure 4B)

While this might sound beneficial, the concern is that it could cause blood pressure to drop lower than intended

Evolutionarily, GSH has been one of the key nucleophilic chemicals in living organisms that convert a range of electrophilic compounds into a less toxic form [120, 121]

Accumulated preclinical studies have verified that ferroptosis inducers can overcome this challenge through multiple pathways