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In addition to mitochondrial dysfunction and surplus ROS production, several apoptosis-associated mediators such as p38, p21, mitogen-activated protein kinase (MAPK), and caspase 2, 3 and 9 can worsen the pathology of disease (Obulesu and Lakshmi, 2014

The review included questionnaires and case reports that described people developing manic episodes and other mood symptoms such as agitation, alertness, insomnia, and impulsivity after very high, short-term intake of energy drinks (for example, six to nine small cans per day over days to weeks)