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Pleiotropic effects of moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in cancer progression, invasiveness, and metastases
This process relies on the Smad signaling pathway and can be blocked by inhibiting the PI3K/AKT/HIF-1 pathway to disrupt TGF-1-induced metabolic reprogramming and EMT (116)
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The water-scaled metabolite levels in mmol/kg were computed using the following equations 34,35 : where S GSH and S H2O represent the GSH and water signal integrals, respectively
