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It has been found that meldonium primarily exerts its therapeutic effects on OGD/R neurons through the activation of the Akt/GSK-3 signaling pathway, therefore inhibiting the mitochondria-dependent neuronal apoptosis [31, 32]
In the previous study, superficial femoral artery FMD was improved as a result of taking 10 g of Cit supplement daily for 4 weeks in hypertensive postmenopausal women [93]
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