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This generally occurs within 1224 h of the first dose and is presumably the result of tumour lysis syndrome
It would, however, give state-licensed compounding pharmacies a clearer path to prepare them for patients holding a valid prescription

Supernatants were collected and centrifuged at 1000 g , 4 C for 10 min to remove dead cell debris

The assay was validated according to local procedures: the FDA 2018 guideline on validation of bioanalytical methods [17], the EMA 2011 guideline on validation of bioanalytical methods [18] and current practice
