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Pugliese G, Penno G, Natali A, Barutta F, Di Paolo S, Reboldi G, Gesualdo L, De Nicola L, Italian Diabetes Society and the Italian Society of Nephrology

The delta-9-THC/CBD combination treatment also decreased levels of the pro-inflammatory cytokines (IL-17, INF-, TNF-, IL-1, and IL-6), and increased anti-inflammatory types including IL-4, IL-10, and TGF- [47]

However, longterm administration frequently leads to motor fluctuations and dyskinesia, affecting approximately 50% of patients within 5 years
