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The progression of DIE lesions is also influenced by the Wnt/-catenin pathway activation, increasing stromal cell proliferation, migration, and contraction of collagen (Fig

In contrast, senomorphics work by modulating the SASP or altering the cellular environment to alleviate the negative effects of senescence without eliminating the senescent cells themselves.5 Both approaches offer a unique opportunity to delay the onset of age-related diseases and extend the healthspan, the period of life spent in good health
