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Neuron-like activation of microglia and astrocytes induces pro-inflammatory mediator expression including such as cytokines (interleukin (IL)-1, tumor necrosis factor (TNF)-, complementary components, acute-phase protein (Smith et al., 2012), which can stimulate inducible nitric oxide synthase (iNOS) and NO production with abnormal phagocytic activity (Lyman et al., 2014) (Figure 2)

[DOI] [PMC free article] [PubMed] [Google Scholar] 185.Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, deRoos P, Liu H, Cross JR, Pfeffer K, Coffer PJ, Rudensky AY

doi: 10.1523/JNEUROSCI.1618-06.2006 73 IkegamiKWatanabeYNakamuraSGotoTInoueNUenoyamaYet al

While clinical studies have demonstrated its fat-reducing potential, AOD-9604 has not been fully validated as an FDA-approved weight loss therapy