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Moreover, free radicals generate many changes in the membranes of nerve cells, such as those occurring due to lipid peroxidation (such as polyunsaturated fatty acidsmembrane phospholipids), modification of membrane enzyme activity, oxidation of membrane protein thiol groups, disturbance of membrane transport, change of the antigenic character of membranes and deregulation of membrane potential [111]

The release of heme, following the rupture of HO-1 / macrophages, caused further tissue inflammation, with initial splenic enlargement progressing to red pulp fibrosis, atrophy, and functional hyposplenism, that recapitulated the asplenia of an HO-1deficient patient

Implementation of digital health technology in clinical trials: the 6R framework

[Google Scholar] 101.Pickering I.J., Wright C., Bubner B., Ellis D., Persans M.W., Yu E.Y., George G.N., Prince R.C., Salt D.E