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1 H NMR (400 MHz, CDCl 3 ) 8.67 (t, J = 1.6 Hz, 1H), 8.50 (s, 2H), 8.28 (d, J = 7.8 Hz, 1H), 8.20 (s, 1H), 7.98 (d, J = 8.0 Hz, 1H), 7.69 (d, J = 7.8 Hz, 1H), 7.56 (m, 3H), 7.43 (t, J = 7.7 Hz, 1H), 7.02 (d, J = 9.7 Hz, 1H), 3.96 (d, J = 5.9 Hz, 2H), 2.92 (d, J = 11.4 Hz, 2H), 2.30 (s, 3H), 1.97 (m, 2H), 1.93 1.82 (m, 6H), 1.52 1.41 (m, 2H)

Since is positivenegativeincreasingdecreasing when is positive and positivenegativeincreasingdecreasing when is negative, we see Since is increasing when is positivenegativeincreasingdecreasing and decreasing when is positivenegativeincreasingdecreasing , we see Hence , , and

coli chemosensory circuit, we posit that inhibition is proportional to the fraction of active receptors (S1 parts 13 and Appendix Table S1