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Evidence gradient matters: Strong mechanistic/preclinical signal proven clinical outcomes in broad populations

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having end-feet projections through which they interact with the ECs [28]

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3 It is caused by recessive pathogenic variants in TNXB resulting in deficiency of TN-X

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We also used MALDI-MSI to examine brain-region-specific alterations of glycerophospholipids and sphingolipids in dopaminergic and serotonergic prosaposin (PSAP)-deficient mouse models, revealing information on the role of PSAP in the maintenance of lipid metabolism in dopaminergic neurons 43

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