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This action protects the cell from programmed death, simultaneously safeguarding senescent cells from apoptosis [111]

Some patients may experience hunger-related sleep disruption as they adjust to decreased appetite and smaller portions
Not surprisingly, employment of siponimod in SPMS has been observed to slow gray matter atrophy and reduce peripheral levels of neurofilament light chain (164)

Current comparisons rely on separate trials with different designs, populations, doses, durations, and endpoints
