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Common regimens include 50 mg/kg intraperitoneally twice daily for 1228 days in C57BL/6J or ob/ob mice, with indirect calorimetry and body-composition endpoints

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In patients with severe renal impairment (CL crless than 30 mL/min/1.73 m 2) not on hemodialysis, the recommended starting dosage is 5 mg once daily and should not exceed 10 mg once daily [see Warnings and Precautions (5.1)and Use in Specific Populations (8.6)]