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In the study, TRIM21 facilitated the clearance of antibody bound intracellular tau aggregates, thereby enhancing the therapeutic effect and cognitive improvements in the mice model

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Additionally, the IL-33/PAR2 signaling in bronchial epithelium augments the type 2 inflammation and airway hyperresponsiveness by promoting the interaction between airway epithelial and mast cells, which is discussed in detail in the Supplementary Data (see Supplementary Figure 2A )