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Carnitine regulatory abnormalities have been attributed to diabetic complications, trauma, hemodialysis, starvation, obesity, cardiomyopathy, fasting, endocrine imbalances, medication interactions, and other conditions (Guerra et al., 2021)

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Higher doses (2000 mg/day) likely saturate hepatic OCTN2 transporters and elevate intracellular carnitine sufficiently to activate CPT1-mediated fatty acid oxidation

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