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Intranasal BBB bypass is a validated human pharmacological route actively used for other biologics (e.g., intranasal oxytocin and insulin)

However, the hypothesis that restoring gut health could play a key role in managing ME/CFS emphasizes the importance of integrating microbiome research into current therapeutic frameworks, thereby advancing the understanding and treatment of this complex and multifaceted condition [1]

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Cartilage-focused research, including work summarized in the NIH PubMed database, explored chondrocyte effects relevant to joint repair models and suggested a potential adjunct role alongside established biologics