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This series of chain reactionsfrom endocrine disturbance (hyperandrogenism) to cellular events (granulosa cell senescence), to microenvironmental alteration (SASP-induced inflammation) and metabolic interaction (AGERAGE axis)collectively constitutes the pathological basis for the premature decline of ovarian function in patients with PCOS

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Good mitochondrial function is also essential for protecting the body against cardiovascular disease, metabolic dysfunction, diabetes, and neurodegenerative diseases