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4.3 Novel therapeutic approaches In recent years, with the continuous advancement of science and technology, numerous novel approaches have emerged in the field of targeted therapy for ECD in AS

Although experimental validation of PRODHs role in ferroptosis remains limited across various model systems, a recent study demonstrated that PRODH suppresses tamoxifen-induced ferroptosis in breast cancer cell lines, suggesting a context-dependent antiferroptotic function 102

This study was supported by an Agios Pharmaceuticals Inc., research collaborative grant and a PRIN 2020 grant (2020Z22PM7)both to LDF
