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But do B12 injections actually promote weight loss

There, gastric acids and enzymes begin breaking down the supplement before it travels to your small intestine

Phase III trials showed fat loss but the total body weight endpoint was not met for regulatory purposes

Subcutaneous injection is the most common research-context format today, but no published human pharmacokinetic study has formally characterized subcutaneous AOD-9604 (this gap was specifically called out in FDA's December 2024 review)
