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In contrast, multiple transgenic models of senescent cell depletion and treatment with senolytics have been demonstrated to not only alleviate, but also delay the onset of age-associated disorders

Beyond protease resistance, acetylation neutralizes the positive charge at the N-terminus, altering the peptides overall charge distribution and potentially influencing membrane permeability

Bode-Lesniewska, B., Fritz, C., Exner, G

Pickart L, Thaler MM (1973)
