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It is due to the copper ions from the blue copper peptide
DHEA(S)-to-Cortisol Ratios Unlike DHEA(S) concentrations that decline under conditions of chronic stress and medical illness, cortisol concentrations generally either rise or do not change, and subsequently result in a decrease in DHEA(S)-to-cortisol ratios [89
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In other words, several of us with mid-range B12 still saw symptoms related to inadequate levels of B12