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225 Inflammatory markers: Neutrophil-to-lymphocyte ratio (NLR) and IL-1 receptor antagonist (IL-1RA) levels correlate with DPN severity, indicating the role of inflammation

Mechanism of Action in Laboratory Research Modulation of intracellular signaling pathways Enhancement of growth factor sensitivity in research models Regulation of gene expression patterns Influence on mitochondrial ATP production and energy metabolism Support of enzymatic activation and pathway mapping studies Primary Research Applications Metabolic Signaling Research: Investigating intracellular signaling cascades related to metabolic regulation

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Persistent cases warrant re-evaluation: advanced vestibular testing (VEMP, ENG), MRI to rule out central lesions, or referral to an otoneurologist