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The latter includes compounds like piperlongumine, which selectively activates oxidative stress responses in cancer cells by interacting with proteins that regulate oxidative stress, such as CBR1, GSTP1, and their complexes, thereby inducing cancer cell death under high ROS levels 119

The study authors note directly that this tissue accumulation is the source of long-term concern not acute poisoning, but the steady, dose-dependent loading of a neurotoxin into the brain, kidneys, liver, and other tissues over years of exposure

The hypothesis requires testing across all races and among people who are free of cardiac risk factors, individuals with early and progressing metabolic derangements, and those who have existing chronic disease diagnoses

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