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SLC7A11 is regulated by two transcription factors, nuclear factor erythroid 2-related factor 2 (NRF2) and activator of transcription 4 (ATF4), according to extensive research
48 who demonstrated that the co-presence of nitrites (NO 2 ) and hydrogen peroxide (H 2 O 2 ) in plasma-treated water leads to the formation of peroxynitric acid (ONOOH), which subsequently decomposes into superoxide anion (O 2 )
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However, randomized trials on its potential use for cancer prevention have mostly yielded negative results (117, 123)
